汤在祥老师

姓  名：汤在祥

学  历：博士研究生

职  称：教授，博士生导师专    业：医学统计学

2019.7-现今  苏州大学医学部公共卫生学院 教授，博士生导师

2021.5-现今   XX生物科技有限公司，顾问专家

2018.7-现今   XX生物科技有限公司，首席顾问专家

2013.7-2019.7    苏州大学医学部公共卫生学院 副教授，硕士生导师

2017.5-2018.6 苏州悦宁生物科技有限公司数据统计部负责人

2015.9-2017.2    美国阿拉巴马大学伯明翰分校生物统计系 国家公派高级访问学者

2011.9-2014.11    公共卫生与预防医学博士后流动站 博士后

2010.8-2013.7    苏州大学医学部公共卫生学院 医学统计学 讲师

主要面向医学类本科生，硕士，博士生和外国留学生，讲授《医学统计学》，《多元统计学》，《医学科研方法》，《Medical Statistics》等课程。

（1） 生物统计学理论与方法，包括高维数据分析，贝叶斯统计学，医疗大数据分析；

（2） 大数据挖掘与预测模型，包括肿瘤大数据挖掘，临床预测模型；

（3） 临床试验设计与统计分析。

美国阿拉巴马大学伯明翰分校生物统计系  国家公派高级访问学者

中国卫生信息学会卫生统计理论与方法专业委员会常务委员中国统计教学学会生物医学统计分会专业委员会 委员

中国医药教育协会医药统计专业委员会常务委员中国肿瘤协会肿瘤人工智能专业委员会 常务委员江苏省健康管理学会，常务委员，特聘专家

江苏省预防医学会卫生统计方法专业委员会  委员

《中国比较医学杂志》编委，《中国实验动物学报》通讯编委

多个SCI杂志的评审人，Frontierin Genetics、Frontier in Oncology客座主编国家自然科学基金的评审专家

1.   国家自然科学基金委员会，面上项目，81773541，高维遗传数据预测模型构建中组群结构信息整合的新方法及其应用研究，2018-01至2021-12，55万元，在研，主持

2.  2019年度省部共建放射医学与辐射防护国家重点实验室，开放课题，GZK1201919， 基于泛癌症图谱的放疗敏感性基因挖掘方法与相关基因验证研究，2019-06至2020-12，3万元，结题，主持

3.   国家自然科学基金委员会，面上项目，81573253，整合遗传高维数据的贝叶斯多水平疾病风险预测模型构建方法与应用研究，2016-011至2017-12，25万元，结题，主持

4.    江苏省科学学技术厅， 江苏省重点研发计划专项, 社会发展- 临床前沿技术， BE2018657，肠道菌群变化特征作为肠道核辐射损伤早期诊断生物标志物的临床研究，2018-07至2021-06，400万元，在研，主要参与（排名第2）

5.   国家自然科学基金委员会，面上项目，31271336，启动子区域遗传多态性位点与骨质疏松关联机制研究，2013-01至2016-12，81万元，已结题，参与

6.   国家自然科学基金委员会，青年项目，81202270，杀伤细胞免疫球蛋白样受体基因多态性与高血压的关系，2013-01至2015-12，23万元，已结题，参与

7.   江苏省级重点实验室，开放课题，K12004，基于多群体的核质互作基因定位方法研究，2013-01至2015-12，2.0万元，已结题，主持

8.    中国博士后基金，2012M521116，基于二维扫描的核质互作基因-QTL定位方法研究，

2013.1至2014.10，5.0万元，已结题，主持

9.   国家自然科学基金委员会，青年基金，31100882，基于虚拟标记插入的核质互作基因定位方法研究，2012-01至2014-12，25万元，已结题，主持

10.   江苏省博士后基金，1202045C，模式动物核质互作基因-QTL定位方法研究，2012-06 至2013-10，2.0万元，已结题，主持

2011年度优秀共产党员

2012年度优秀班主任

2012年度考核优秀

2012年获教育部高等学校科学研究优秀成果奖（自然科学奖）二等奖

2017年度考核优秀

2018年获江苏省预防医学会2017年度优秀委员表彰1项

2018年全国高校（医学类）微课教学比赛二等奖

2018年苏州大学第十七届青年教师课堂教学竞赛二等奖

2018年指导本科生以“皮肤那些事儿”科普图文，获中国国际科普大赛三等奖

2018年校优秀本科生毕业论文指导教师

2018年江苏省优秀本科生毕业论文指导教师

2019年度苏州大学优秀教师

2020年度苏州大学“建设银行奖教金” 二等奖

1.                       张明芝；李红美；吕大兵主编；汤在祥(第一副主编)；裴育芳；实用医学统计学与SAS应用（第九、十三、十四、十六、十七、十九、二十二、二十四章），苏州大学出版社，960千字，2015

2.                       李正奇；赵俊主编；余珊珊；程国华；郝晓花；吴建龙；王文萍，黄晓钟；汤在祥等参编，生物等效性试验实用指南（第十四章 生物等效性试验数据统计分析），江苏凤凰科学技术出版社，400千字，2018

2.    苏州大学（汤在祥）；放疗敏感性基因标签发现与验证软件 V1.0（计算机软件著作权）， 2017-10-21，中国，2019SR1087718

3.    苏州大学（汤在祥）；临床预测模型构建软件（计算机软件著作权）， 2020-07-24，中国， 2020SR0827064

参与化药生物等效性研究 40 余项，药品包括阿托伐他汀钙、匹伐他汀、硝苯地平、富马酸替诺福韦、替硝唑、盐酸普拉克索、盐酸乙胺丁醇、阿哌沙班、他达拉非等；参与二三期药物临床试验项目多项。参与医疗器械项目 20 余项，包括 IVD、丝素蛋白凝胶、中医舌诊仪、中医脉诊仪等。具有丰富的临床试验设计与数据分析管理经验。

先后发在国际主流学术期刊《Bioinformatics》、《Heredity》、《Genetics》、《IVOS》、

《Frontier Oncology》等杂志上发表SCI论文40余篇，有关研究成果应邀在国际数量遗传学大会（2012，英国爱丁堡）、中国卫生统计年会（2015，太原）、美国泛华统计年会（2016， 亚特兰大），中国卫生统计年会(2017，武汉)，泛华统计年会（2018，青岛）等学术会议报告。主要代表作如下：

(1)      Du Zixuan, Zhang Xinyan, Tang Zaixiang*. More evidence for prediction model of radiosensitivity. Biosci Rep. 2021 Apr 30;41(4):BSR20210034. doi: 10.1042/BSR20210034 (InvitedCommentary)

(2)     Liting Huang, Ying Liu, Huijun Li, WeicunHuang, Ruirui Geng, Zaixiang Tang(Co-Corresponding authors) and Yiguo Jiang. Bullous Pemphigoid and Diabetesmedications: A disproportionality analysis based on the FDA Adverse EventReporting System. Int. J. Med. Sci. 2021, 18: 1946-1952

(3)      Junjie Shen, Congju Wang, Chen Dong, Zaixiang Tang (Co-Corresponding authors),Hongpeng Sun. Reductions in mortality resulting fromCOVID-19 quarantine measures in China. Journal of Public Health, 2021, fdaa249,

(4)    Li Zhongyang, Cai Shang, Li Huijun, Gu Jincheng, Tian Ye, Cao Jianping,Yu Dong, Tang Zaixiang*. Developing a lncRNA Signature to Predict theRadiotherapy Response of Lower-Grade Gliomas Using

Co-expression andceRNA Network Analysis, Frontiers in Oncology, 2021, 11: 185, DOI:10.3389/fonc.2021.622880

(5)    QianqianLiu; Dan Liu; Derui Yan; Weicun Huang; Xiaodong Ji; Jie Hui; Zaixiang Tang* ， Gender-Specific Association Between Serum Uric Acidand Incident High Intraocular Pressure in Chinese Population: A Cross-SectionalStudy, Investigative Ophthalmology & Visual Science (IOVS) 2020, Vol.61,10.

(6)    DongrunXin, Jingfang Liu, Jincheng Gu, Yujie Ji, Jiawei Jin, Lu Sun, Qingliang Tai,Jianping Cao, Ye Tian, Hualong Qin , and ZaixiangTang*. Low Expression of DDX60 Gene Might Associate with theRadiosensitivity for Patients with Breast Cancer. Journal ofOncology, 2020, Volume 2020, Article ID 8309492,

(7)    Qianqian Liu， Chunxing Liu, Yonghui Gao, Xinyan Zhang, Nengjun Yi, JianpingCao, Yamin Wang, Yongbin Jiang & ZaixiangTang*. Gender-Specific Associationbetween Serum Uric Acid and Incident Fundus Arteriosclerosis in ChinesePopulation: A Retrospective Cross-Sectional Study.

Scientific Reports (2020) 10:8595

(8)    Ting Wang, Zaixiang Tang (Co-first), Xinghao Yu,Yixing Gao, Fengjun Guan, Chengzong Li,Shuiping Huang, Junnian Zheng and PingZeng, Birth Weight and Stroke in Adult Life: Genetic Correlation and CausalInference With Genome-Wide Association Data Sets. Front.Neurosci. 2020，14:479.doi: 10.3389/fnins.2020.00479

(9)    Zixuan Du,Derui Yan, Zhongyang Li, Jinche. ng Gu, Ye Tian, Jianping Cao,and Zaixiang Tang*, Genes Involved in thePD-L1 Pathway Might Associate with Radiosensitivity of Patients with GastricCancer. Journal of Oncology Volume 2020, Article ID 7314195, 14 pages

(10)Tang, Zaixiang, SunBei, Xu Bo. A quick evaluation method of nosocomial infection risk for cancer hospitals during the COVID‑19 pandemic. Journal of Cancer Research and Clinical Oncology, 2020,

(11)HaitongSun, Jincheng Gu, Zhongyang Li, Qianqian Liu, Jiaxi Lin, Ye Tian, Jianping Cao,Hualong Qin, and Zaixiang Tang*, LowExpression of GLIS2 Gene Might Associate with Radiosensitivity of GastricCancer. Journal of Oncology, 2019:2934925.

(12)Manzhongsong, Chen Tao, Zhu zhongwei, Zhang Haitao Ao Lei,Xi Liting, Zhou Jin, Tang Zaixiang*. High expression ofTRIM36 is associated with radiosensitivity in gastric cancer. Oncologyletter. 2019, 17:4401-4408

(13)Hu Huagang;Yu Xiang; Tang Zaixiang; Lin Lu. Research Capacity and Research Training Needsof Clinical Nurses in Suzhou, China. The Journal of Continuing Educationin Nursing, 2019, 50(9): 423-432

(14) Zhuo Wang, Wei Ding*, Qi Fang*, Lulu Zhang, XueyunLiu, Zaixiang Tang，Effects ofnot monitoring gastric residual volume in intensive care patients: Ameta-analysis, International Journal of Nursing Studies, 2019, 91: 86–93

(15)Nengjun Yi,Zaixiang Tang, Xinyan Zhang, BoyiGuo; BhGLM: Bayesian hierarchical GLMs and survival models, with applicationsto genomics and epidemiology, Bioinformatics, Bioinformatics, 35(8), 2019, 1419–1421

(16)Tang Zaixiang, Lei Shufeng, Zhang Xinyan, Yi Zixuan, Guo Boyi, Chen Jake Y., ShenYueping, Yi Nengjun, Gsslasso Cox: a Bayesian hierarchical model for predictingsurvival and detecting associated genes by incorporating pathway information. BMCBioinformatics, 2019, 20(1): 20-94.

(17)TangZaixiang, Shen Yueping, Li Yan, Zhang Xinyan, Wen Jia, Qian Chen'ao,Zhuang Wenzhuo, Shi Xinghua, Yi Nengjun. Group spike-and-slab lasso generalized linear models for diseaseprediction and associated genes detection by incorporating pathway information.Bioinformatics, 2018, 34(6): 901-910.

(18)Ji Ye,Jiang Qinghua, Jian Guohao, Sun Haitong, Wang Yamin, Qin Hualong, Zhang Shuyu,Cao Jianping, Tang Zaixiang.Developing a radiosensitivity gene signature for Caucasian patients with breastcancer. Oncology reports, 2018, 40:1695-1705.

(19)QinHualong#, Zhou Jun#, Xu Jingjing, Cheng Li, Tang Zaixiang, Ma Haitao and GuoFeng* The nuclear transcription factor RelB functions as an oncogene in humanlung adenocarcinoma SPC?A1 cells. Cancer Cell International, 2018,18: 88

(20)Cui-LinShi, Jun-Chi Xu, Hui Chen, Zhi-Jian Ye, Xin-Nian Chen, Pei-Jun Tang, Li-LingMa, Zai-Xiang Tang, Mei-Ying Wu,Ping Xu. Risk factors of latent tuberculosis infection and immune function inhealth care workers in Suzhou, China. Journal of Thoracic Disease. 2018，10(12): 6742-6752.

(21)Tang Zaixiang, Shen Yueping, Zhang Xinyan, Yi Nengjun. The spike-and-slab lasso Coxmodel for survival prediction and associated genes detection. Bioinformatics,2017, 33(18): 2299-2807.

(22)Tang Zaixiang, Shen Yueping, Zhang Xinyan, Yi Nengjun. The Spike-and-Slab Lassogeneralized linear models for prediction and associated genes detection. Genetics,2017, 205(1): 77-88.

(23)Tang Zaixiang, Zeng Q, Li Y, Zhang X, Ma J, Suto MJ, Xu B, Yi N. Development of aradiosensitivity gene signature for patients with soft tissue sarcoma. Oncotarget.2017, 18(16):27428-27439. doi: 10.18632/oncotarget.16194

(24)Tang Zaixiang, Qinghua Zeng, Yan Li, Xinyan Zhang, Mark J. Suto, Bo Xu and NengjunYi. Predicting radiotherapy response for patients with soft tissue sarcoma bydeveloping a molecular signature, oncology reports, 2017, 38: 2814-2824,

(25)Jin Zhou,Xiaoyu Wu, Gang Li, Xin Gao, Min Zhai, Weichang Chen,Huagang Hu and Zaixiang Tang*, Prediction ofradiosensitive patients with gastric cancer by developing gene signature.

International journal of oncology 2017, 51: 1067-1076

(26)Wang, Z.,M. Shen, M. Qiao, H. Zhang and Z. Tang (2017)."Clinical factors and incidence of prolonged fever in neurosurgicalpatients." J Clin Nurs 26(3-4): 411-417.

(27)XinyanZhang, Yan Li, Zaixiang Tang andNengjun Yi*, Statistical Methods in Precision Medicine: Employing SystemsBiology for Cancer Survival Prediction. Journal of Biometrics &Biostatistics, 2016,7:1

(28)Wang, X.,Q. Zhi, S. Liu, S. L. Xue, C. Shen, Y. Li, C. Wu, Z. Tang, W. Chen, J. L. Song, M. Bao, Y. H. Song and J. Zhou(2016). "Identification of specific biomarkers for gastric adenocarcinomaby ITRAQ proteomic approach." Sci Rep 6: 38871.

(29)Qin, H., J.Zhou, P. Zhou, J. Xu, Z. Tang, H. Ma and F. Guo (2016). "Prognosticsignificance of RelB overexpression in non-small cell lung cancerpatients." Thorac Cancer 7(4): 415-421.

(30)Zhu, X. W.,F. Y. Deng, L. F. Wu, Z. X. Tang and S. F. Lei (2015). "Functionalmechanisms for type 2 diabetes-associated genetic variants." J DiabetesComplications 29(4): 497-501.

(31)Wang, L.,L. F. Wu, X. Lu, X. B. Mo, Z. X. Tang, S. F. Lei and F. Y. Deng (2015)."Integrated Analyses of Gene Expression Profiles Digs out Common Markersfor Rheumatic Diseases." PLoS One 10(9): e0137522.

(32)Qiu, Y. H.,F. Y. Deng, Z. X. Tang, Z. H. Jiang and S. F. Lei (2015). "Functionalrelevance for type 1 diabetes mellitus-associated genetic variants by usingintegrative analyses." Hum Immunol 76(10): 753-758.

(33) Zhou, W., Z.Tang(co-first), J. Hou, N. Hu and T. Yin (2015). "Genetic MapConstruction and Detection of Genetic Loci Underlying Segregation Distortion inan Intraspecific Cross of Populus deltoides." PLoS One10(5): e0126077.

(34)Zaixiang Tang, Wenming Hu, Jian Huang, Xin Lu, Zefeng Yang, Shufeng Lei, YonghongZhang, Chenwu Xu. Potential Involvement of Maternal Cytoplasm in the Regulationof Flowering Time via Interaction with Nuclear Genes in Maize. Crop Sci.54:544–553 (2014).

(35)TangZaixiang, Yang Zefeng, Hu Zhiqiu, Zhang Dan, Lu Xin, Jia Bo, DengDexiang, Xu Chenwu. Cytonuclear epistatic quantitative trait locusmapping for plant height and ear heightin maize.

MolecularBreeding. 2013, 31: 1-14

(36)Tang, Z.X., X. F. Wang, M. Z. Zhang, Y. H. Zhang, D. X. Deng and C. W. Xu (2013)."The maternal cytoplasmic environment may be involved in the viabilityselection of gametes and zygotes." Heredity (Edinb) 110(4): 331-337.

(37)Tang Zaixiang, Xiao Jing, Hu Wenming, Yu Bo, Xu Chenwu. Bin-based model constructionand analytical strategies for dissecting complex traits with chromosome segmentsubstitution lines.

Chinesescience bulletin. 2012, 57(21):2666-2674

(38)Tang Zaixiang, Hu Zhiqiu, Yang Zefeng, Yu Bo, Xu Chenwu. Framework for dissection ofcomplex cytonuclear epistasis by a two-dimensional genome scan. Chinesescience bulletin. 2012, 57(21): 2675-2680

(39) Shuxian Li, Zaixiang Tang, Defang Zhang, Ning Ye,Chenwu Xu, Tongming Yin. Genome-wide detection of genetic loci triggeringuneven descending of gametes from a natural hybrid pine. TreeGenetics & Genomes.2012, 8: 1371-1377

(40)Tang Z,Wang X, Hu Z, Yang Z, Xu C (2007) Genetic dissection of cytonuclear epistasisin line crosses. Genetics 177: 669-672